What makes this formula unique is that the synergism of its broad-range nutrients address multiple concerns related to hormone balance with special emphasis on estrogen activity and metabolism. Because it exerts multiple influences, Premier Estro Complex is an excellent choice for a variety of women’s concerns. Its hormone-balancing support may provide relief for women with estrogen-excess concerns as well as providing effective nutritional support to encourage healthy estrogen balance in menopausal women.*
 

To enable its detoxification, estrogen goes through a process called hydroxylation that yields the so-called “good” 2-hydroxyestrone (2-OH) estrogen and the less desirable 16-hydroxyestrone (16-OH) and 4-hydroxyestrone (4-OH) estrogens. Because these estrogen metabolites vary greatly in their level of estrogenic activity, their ultimate effect on the body’s tissues (whether beneficial or stressful) depends on how they are processed in the body.
The 2-OH estrogen has weak estrogenic activity, while 4-OH and 16-OH estrogens show long-acting estrogenic activity and are often associated with estrogen-excess related health concerns. Both 2-OH and 4-OH estrogens (called catechol estrogens) can be readily oxidized to quinones, which are highly reactive and can damage DNA.
However, this oxidation process can be altered if the catechol estrogens are first detoxified via Phase II liver detoxification (methylation). Therefore, the goal is to achieve an adequate nutritional status so that the liver can easily render 4-OH less reactive, while supporting the beneficial properties of 2-OH. Thus, we can see that supporting the liver detoxification pathway is a critical factor in supporting overall healthy estrogen activity.